论文部分内容阅读
目的观察治疗剂量的格列吡嗪对糖尿病模型大鼠肾脏功能的影响。方法雄性成年SD大鼠腹腔内注射链脲佐菌素(STZ)诱发糖尿病,模型成功后给予格列吡嗪灌胃,连续给药12周。检测第12周的大鼠血尿素氮(BUN)、肾重/体重、尿微量白蛋白排泄率(UAER)、肾小球基质面积及截面积,光镜下观察肾脏病理改变,并作对照比较分析。结果使用格列吡嗪药物组的BUN、UAER、肾重/体重、肾小球基质面积及截面积相对于糖尿病模型组和阴性对照组均明显升高,差异有统计学意义(P<0.05),同时肾脏病理损伤更重。结论格列吡嗪能够损害糖尿病模型大鼠肾功能,加重肾脏病理损害,促进糖尿病肾病的进展。
Objective To observe the effects of therapeutic dose of glipizide on renal function in diabetic rats. Methods Adult male Sprague-Dawley rats were intraperitoneally injected with streptozotocin (STZ) to induce diabetes. After the model was successfully treated, glipizide was given intragastrically for 12 weeks. Blood urea nitrogen (BUN), renal weight / body weight, urinary albumin excretion rate (UAER), glomerular matrix area and cross-sectional area were measured at the 12th week. The pathological changes of the kidneys were observed under light microscope. analysis. Results The BUN, UAER, renal weight / body weight, glomerular matrix area and cross - sectional area of glipizide group were significantly higher than those of diabetic model group and negative control group (P <0.05) , While kidney damage more serious. Conclusion Glipizide can impair renal function, increase renal pathological damage and promote the progression of diabetic nephropathy in diabetic rats.