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应用单向免疫扩散法,对40例肾病综合征病儿血清α_1-抗胰蛋白酶(α_1-AT)进行了测定,并与30例对照组进行了比较.结果表明,单纯性和肾炎性肾病综合症在急性期的血清α_1-AT分别为1.84±0.63g/L和1.80±0.72g/L,较对照组的3.13±0.89g/L均显著降低(均为P<0.01),但两型间无差异;本组恢复期肾病综合症血清α_1-AT为2.97±0.84g/L,与对照组相比较无显著性差异(P>0.1).提示α_1-AT降低是继发性的且与病理类型无关,对α_1-AT进行监测有利本病鉴别诊断、了解病情及指导治疗.
One-way immunodiffusion method was used to measure the serum level of α_1-antitrypsin (α_1-AT) in 40 children with nephrotic syndrome and compared with 30 control subjects.The results showed that the simple and nephritic nephrotic syndrome The serum levels of α_1-AT in acute phase were 1.84 ± 0.63g / L and 1.80 ± 0.72g / L, respectively, which were significantly lower than those in the control group (3.13 ± 0.89g / L, all P <0.01) There was no difference between the two groups. The serum level of α_1-AT in nephrotic syndrome was 2.97 ± 0.84g / L in the recovery stage of nephrotic syndrome group, showing no significant difference compared with the control group (P> 0.1), suggesting that the decrease of α_1-AT is secondary to pathology Type has nothing to do, the monitoring of α_1-AT beneficial differential diagnosis of the disease, to understand the condition and guide the treatment.