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目的评价结核感染T细胞斑点试验(T-SPOT.TB)在结核性疾病中的诊断价值。方法采用T-SPOT.TB试剂盒对疑诊或待排结核患者外周血中特异性T淋巴细胞进行检测。结果结核感染T细胞斑点试验对结核病的敏感度、特异度、阳性预测值、阴性预测值依次为76.7%、84.3%、83.9%、77.2%。结核组的阳性率显著高于非结核组,差异有统计学意义(P<0.05)。结论结核感染T细胞斑点试验是诊断结核的快速敏感方法,值得在临床中推广使用。
Objective To evaluate the diagnostic value of T-SPOT.TB in tuberculosis. Methods T-SPOT.TB kit was used to detect the specific T lymphocytes in the peripheral blood of suspected or pending TB patients. Results The sensitivity, specificity, positive predictive value and negative predictive value of T-cell stain test for tuberculosis were 76.7%, 84.3%, 83.9% and 77.2%, respectively. The positive rate of tuberculosis group was significantly higher than that of non-tuberculosis group, the difference was statistically significant (P <0.05). Conclusion Tuberculosis infection T cell spot test is a rapid and sensitive method for diagnosis of tuberculosis and is worth popularizing in clinic.