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Toll样受体是自身免疫的关键受体,它参与宿主对致病微生物的识别和防御等感染免疫过程,也与人体的获得性免疫密切相关,是目前免疫学研究的重点和热点。眼球作为感染性和免疫性疾病的好发部位,在感染免疫和获得性免疫方面与全身其他器官有相似之处,但是其独特的解剖特点,例如血房水屏障、血视网膜屏障、角膜的无血管化等,使其免疫学特点的特异性也非常明显。就Toll样受体的特点以及在眼科的研究现状进行综述。
Toll-like receptors are the key receptors of autoimmunity. They are involved in immune processes such as identification and defense of pathogenic microorganisms, and are also closely related to the acquired immunity of the human body. Toll-like receptors are the focus and hot point of current immunological research. Eyeballs, as the predilection sites for infectious and immunological diseases, have similarities with other organs in the body in terms of both infectious and acquired immunity, but their unique anatomical features such as blood-water barrier, blood-retinal barrier, corneal Vascularization, etc., so that the specificity of its immunological characteristics are also very obvious. The characteristics of Toll-like receptors and the status of research in ophthalmology are reviewed.