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甲基丙烯酸与溴化氢反应得到３－溴－２－甲基丙酸，后者经用氯化亚砜氯化、与Ｌ－脯氨酸缩合得到缩合酸．缩合酸再经分拆、巯基化得到卡托普利．
Methacrylic acid is reacted with hydrogen bromide to give 3-bromo-2-methylpropionic acid, which is chlorinated with thionyl chloride to condense with L-proline to yield the condensed acid. Condensation acid and then spin-off, mercapto-captopril.