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目的:观察三维适形放射治疗胰腺癌的疗效。方法:选择胰腺癌患者20例(胰头癌13例,胰体癌4例、胰尾癌3例)接受三维适形放射治疗,其中病理证实12例(导管癌7例,粘液癌3例,囊腺癌2例)放疗总剂量40~50GY/12~15F/每周5次,对其临床症状缓解情况,放疗反应进行评估。每3个月复查MR或CT一次,第二年每6个月复查MR或CT一次。结果:截止2002年9月共随访20例。疗效判定标准:按WHO制订标准,完全缓解CR4例,占20%,部分缓解PR16例,占80%,稳定0例,进展NC0例,总有效率(CR+PR)为100%,症状缓解率为100%,1、2年生存率分别为90.6%、72%,放射性急性胃肠反应发生率为43.6%。结论:三维适形放射治疗胰腺癌具有明显剂量分布优势,局部控制率和症状缓解率高,放射性胃肠炎发生率低。
Objective: To observe the efficacy of three-dimensional conformal radiotherapy in pancreatic cancer. Methods: Twenty patients with pancreatic cancer (pancreatic carcinoma of the pancreas in 13, pancreatic carcinoma in 4 and pancreatic cancer in 3) were selected for three-dimensional conformal radiotherapy. Among them, 12 were pathologically confirmed (ductal carcinoma in 7, mucinous carcinoma in 3, 2 cases of cystadenocarcinoma) radiotherapy total dose of 40 ~ 50GY / 12 ~ 15F / 5 times a week, its clinical symptoms, radiotherapy response assessment. MR or CT is reviewed every 3 months and MR or CT is reviewed every 6 months in the second year. Results: As of September 2002, a total of 20 cases were followed up. Criteria of Efficacy: According to the standard set by WHO, CR4 was completely relieved, accounting for 20%; partial remission PR16, accounting for 80%, stable 0, progression NC0, total effective rate (CR + PR) 100%. The 1-year and 2-year survival rates were 90.6% and 72%, respectively. The incidence of acute radioactive gastrointestinal reactions was 43.6%. Conclusion: Three-dimensional conformal radiotherapy for pancreatic cancer has the advantages of obvious dose distribution, high local control rate and symptom relief, and low incidence of radioactive gastroenteritis.