目的探讨神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病(HIE)的临床疗效及对神经功能的改善作用。方法选择2014年1月-2016年1月奉化市人民医院收治的68例HIE患儿为研究对象,随机分为研究组(34例)和对照组(34例)。对照组患儿在常规治疗基础上给予纳洛酮治疗,研究组患儿应用神经节苷脂联合纳洛酮进行治疗。7 d为1个疗程。连续治疗两个疗程。评估两组患儿临床疗效,采用中国新生儿20项行为神经评分法(NBNA)评估患儿治疗前后进行神经行为评分,记录两组患儿临床主要症状或体征恢复时间。结果研究组患儿显效率为55.88%,对照组为44.18%,两组比较,差异具有统计学意义(P<0.05);研究组患儿意识、肌张力和原始反射恢复时间为(4.01±0.64)d、(4.24±0.43)d和(4.30±0.41)d,均低于对照组,两组比较,差异有统计学意义(P<0.05)。研究组治疗1个疗程和2个疗程后,NBNA评分分别为(31.17±5.22)分和(38.17±5.22)分,对照组为(30.53±4.86)分和(34.06±5.14)分,且两组治疗后均高于治疗前,治疗2个疗程后高于治疗1个疗程(P<0.05)。结论神经节苷脂联合纳洛酮治疗HIE具有较好的临床疗效,能够显著缩短患儿治疗时间,改善患儿神经功能,促进患儿的康复。 Objective To investigate the clinical efficacy of ganglioside and naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and to improve its neurological function. Methods Sixty-eight HIE children admitted to Fenghuang People’s Hospital from January 2014 to January 2016 were randomly divided into study group (34 cases) and control group (34 cases). Children in the control group were treated with naloxone on the basis of conventional treatment. The children in the study group were treated with ganglioside combined with naloxone. 7 d for a course of treatment. Continuous treatment of two courses. The clinical efficacy of two groups of children was evaluated. Neurobehavioral scores of children were evaluated before and after treatment with 20 newborns behavioral neurological score (NBNA) in China. The main clinical symptoms or signs recovery time were recorded in both groups. Results The effective rate was 55.88% in the study group and 44.18% in the control group. The difference between the two groups was statistically significant (P <0.05). The recovery time of consciousness, muscle tone and the original reflex in the study group was (4.01 ± 0.64 ), d (4.24 ± 0.43) d and (4.30 ± 0.41) d, respectively, were lower than those in the control group. There was significant difference between the two groups (P <0.05). The NBNA score was (31.17 ± 5.22) points and (38.17 ± 5.22) points in the study group and (30.53 ± 4.86) and (34.06 ± 5.14) points in the control group after one course of treatment and two courses of treatment, respectively, and the two groups After treatment were higher than before treatment, after 2 courses of treatment than the treatment of a course of treatment (P <0.05). Conclusion Ganglioside combined with naloxone in the treatment of HIE has good clinical efficacy, can significantly shorten the treatment time in children, improve children’s neurological function, and promote the rehabilitation of children.