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目的比较头孢西丁钠2组不同给药方案中峰时和谷时血清杀菌活性(SBA),研究SBA的测定在评价抗菌药物给药方案中的应用价值。方法收集头孢西丁钠1日3次规范用药组(实验组:1.0 g,q 8 h)患者33例和1日1次用药组(对照组:2.0 g,q 24 h)患者30例,比较2组患者对质控菌株金黄色葡萄球菌和大肠埃希菌的峰时和谷时SBA效价。结果实验组患者对2种质控菌株SBA峰值均为1∶4~1∶32,谷值均为<1∶1~1∶4;对照组患者对2种质控菌株的SBA峰值均为1∶8~1∶64,谷值均<1∶1。增加给药间隔时间会降低谷时SBA效价。2种质控菌株的对照组峰时SBA均高于实验组,差异均有统计学意义(P<0.01)。结论实验组能保证理想的峰时和谷时SBA,对照组易造成峰时药物过量,用药间隔时间过长导致谷时SBA过低影响疗效。SBA测定可作为抗菌药物给药方案评价的重要依据。
Objective To compare the serum bactericidal activity (SBA) of cefoxitin sodium at different time points and troughs in different administration regimens, and to study the value of SBA determination in the evaluation of antimicrobial drug delivery regimens. Methods Thirty patients with cefotetan sodium three times a day (experimental group: 1.0 g, q 8 h) and 30 patients with primary drug once a day (control group: 2.0 g, q 24 h) were enrolled in this study. Peak-hour and valley-hour SBA titer of the two control groups Staphylococcus aureus and Escherichia coli. Results In the experimental group, the peak values of SBA in two kinds of control strains were all from 1: 4 to 1:32, and the troughs were all from 1: 1 to 1: 4. The SBA peak values of the two control strains in the control group were all 1 : 8 ~ 1:64, trough <1: 1. Increasing the dosing interval will decrease the SBA titer during the trough. The SBA of the two control strains at the peak of the control group was significantly higher than that of the experimental group (P <0.01). Conclusion The experimental group can ensure the ideal peak and valley SBA, the control group can easily lead to peak drug overdose, medication interval is too long lead to low SBA valley effect. SBA assay can be used as an important basis for evaluation of antimicrobial drug delivery programs.