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在HBV感染的肝细胞核内可检测到一种不同形式的病毒DNA———共价闭合环状DNA(HBVcccDNA),不与蛋白共价结合,是乙肝病毒基因组的复制中间体,是病毒mRNA和前基因组RNA转录的模板,它的存在是病毒复制的一个重要指标,也是评价HBV感染状态及药物疗效最重要的指标,但取材困难。文献
In HBV infected liver cells can detect a different form of viral DNA - covalently closed circular DNA (HBVcccDNA), is not covalently linked to the protein, is a copy of the hepatitis B virus genome, is the virus mRNA and Pre-genomic RNA transcription of the template, its presence is an important indicator of viral replication, but also to evaluate the status of HBV infection and drug efficacy of the most important indicators, but difficult to draw. literature