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作者用体内、体外方法比较了恶性疟原虫对磺胺多辛(SDX)和乙胺嘧啶(PYR)的敏感性。病例来自东非,经测定,对法西达有Ⅰ～Ⅱ级抗性。于0～7天取血测定血浆药物浓度并进行恶性疟原虫体外培养。从病人
The authors compared the susceptibility of Plasmodium falciparum to sulfadoxine (SDX) and pyrimethamine (PYR) in vitro and in vivo. The cases were from East Africa and were determined to have Class I-II resistance to Faxidac. Blood samples were taken from 0 to 7 days for determination of plasma drug concentration and P. falciparum in vitro culture. From the patient