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目的评价北京市现行乙型肝炎(乙肝)疫苗(HepB)免疫策略的母婴阻断效果。方法利用北京市1999~2004年部分区对母亲乙肝病毒表面抗原(HBsAg)阳性的儿童进行HepB免疫后的血清学监测资料,对母亲HBsAg阳性儿童的血清HBsAg、乙肝病毒表面抗体(抗-HBs)和乙肝病毒核心杭体(抗-HBc)水平以及疫苗保护水平进行分析。结果所监测的727名儿童中,HBsAg阳性率为2.5%。母亲[HBsAg、乙肝病毒膜抗原(HBeAg)]双阳性者HBsAg阳性率高于母亲单阳性者。抗-HBc阳性率为6.1%,母亲单阳性者和母亲双阳性者差异无显著的统计学意义。抗-HBs阳性率为85.7%,抗体几何平均浓度(GMC)为90.4毫国际单位/毫升(mIU/ml),且母亲单阳性者抗-HBs阳性率高于母亲双阳性者。HepB保护率为92.2%(95%CI:90.3%~94.1%),其中对母亲单阳性者的保护率为93.4%(95%CI:92.3%~94.5%),对母亲双阳性者的保护率为89.3%(95%CI:87.2%~91.4%)。结论北京市现行HepB免疫策略对母亲HBsAg阳性儿童的免疫保护效果理想。
Objective To evaluate the maternal and neonatal blocking effect of Hepatitis B (Hepatitis B) vaccine (HepB) vaccination strategy in Beijing. Methods The serological surveillance data of HepB immunized children with HBsAg positive in some areas of Beijing from 1999 to 2004 were used to detect the serum HBsAg, HBsAg (anti-HBs) And hepatitis B virus core antibody (anti-HBc) levels and vaccine protection level analysis. Results Among the 727 children monitored, the positive rate of HBsAg was 2.5%. The positive rate of HBsAg in mothers with HBsAg and HBeAg double positives was higher than that in mothers with single positive. The positive rate of anti-HBc was 6.1%. There was no significant difference in the positive rate of anti-HBc between the single positive mother and the positive mother. The positive rate of anti-HBs was 85.7% and the geometric mean antibody concentration (GMC) was 90.4 milliunits per milliliter (mIU / ml). The positive rate of anti-HBs in males with single positive was higher than those with positive males. The protection rate of HepB was 92.2% (95% CI: 90.3% ~ 94.1%), of which 93.4% (95% CI: 92.3% ~ 94.5%) were protected against single mothers, 89.3% (95% CI: 87.2% -91.4%). Conclusion The current HepB immunization strategy in Beijing is effective for the protection of mothers with HBsAg-positive children.