对药物所致重症多形红斑（ＳＪＳ）和中毒性表皮坏死松解症（ＴＥＮ）进行了对比研究。两者最常见的致敏药物是解热镇痛药，其次是抗生素类和镇静抗癫痫药。ＳＪＳ和ＴＥＮ的发病年龄、性别和潜伏期无差异，但ＴＥＮ的发热时间、急性期和恢复期时间明显长于ＳＪＳ，发热程度、粘膜损害程度和合并症发生率明显高于ＳＪＳ。ＳＪＳ预后良好，无１例死亡。ＴＥＮ的死亡率高达３９％。关于皮质类固醇激素在治疗ＴＥＮ中的应用，我们认为早期短程应用是必要的，同时注意液体与电解质的补充，营养供应和皮肤粘膜的护理。 The drug-induced severe erythema multiforme (SJS) and toxic epidermal necrolysis (TEN) were compared. The two most common sensitizing drugs are antipyretics and analgesics, followed by antibiotics and sedative antiepileptic drugs. There were no differences in the age, sex and latency of SJS and TEN, but the duration of fever, acute phase and recovery of TEN were significantly longer than that of SJS. The incidence of fever, mucosal damage and complication were significantly higher than those of SJS. SJS with a good prognosis, no one died. TEN’s death rate is as high as 39%. With regard to the use of corticosteroids in the treatment of TEN, we believe early short-haul applications are necessary, with attention paid to fluid and electrolyte supplements, nutritional supplies and skin and mucous membrane care.