目的观察介入再通术对慢性闭塞性脑血管病变(chronic total cerebrovascular occlusion,CTO)患者认知功能的改善情况,并与未进行血管再通的CTO患者进行对比。方法选择我院2013年5月至2016年5月收治的CTO患者55例,其中介入再通组(治疗组)21例,非再通组(对照组)34例,比较术后12、24个月认知功能情况,采用简易智能精神状态检查量表(mini-mental state examination,MMSE)、蒙特利尔认知功能评分表(Montreal cognitive assessment,Mo CA)评估患者认知功能。结果治疗组与对照组患者术前美国国立卫生研究院卒中评分量表(national institute of health stroke scale,NIHSS)评分差异有统计学意义(P<0.05),而性别、年龄、文化程度、脑血管危险因素、认知功能等基线资料差异没有统计学意义(P>0.05)。随访期间,两组患者认知功能(12个月后MMSE、Mo CA,24个月后MMSE、Mo CA量表评分)比较差异有统计学意义(P<0.05,P<0.01)。结论介入再通术可以明显改善CTO患者的认知功能。 Objective To observe the effect of interventional recanalization on cognitive function in patients with chronic total cerebrovascular occlusion (CTO) and compare it with that of CTO patients without revascularization. Methods Fifty-five patients with CTO were selected from May 2013 to May 2016 in our hospital. Among them, 21 cases were involved in the recanalization group (treatment group), 34 cases were in the non-recanalization group (control group), and 12 and 24 The cognitive function of patients was assessed by mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA). Results There were significant differences in NIHSS score between the treatment group and the control group before surgery (P <0.05), while the gender, age, educational level, cerebrovascular Baseline data such as risk factors and cognitive function had no statistical significance (P> 0.05). During follow-up, there were significant differences in cognitive function (MMSE, MoCA after 12 months, MMSE, MoCA score after 24 months) between the two groups (P <0.05, P <0.01). Conclusion Interventional recanalization can significantly improve the cognitive function of patients with CTO.