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据报道,健康人口服单剂依那普利(Enalapril),老年组本品清除率和清除率/生物利用度(CL/F)比值均低于青年组,上述指数与内原性肌酐廓清率之间均存在正相关性。作者测定了老年组(65～78岁)和青年组(22～31岁)健康人按日剂量10mg服用依那普利共8天的药动学和药效学。结果:老年组和青年组卧位收缩压最大降低值分别为58±22和25±19mmHg,两组差异显著(P<0.02)。CL/F值分别为每小时11.3±3.0和19.8±5.9 L,内原性肌酐廓清率基础值分别为每分钟64±12和124±19 ml,两者
It is reported that healthy people taking a single dose of enalapril (Enalapril), elderly product clearance and clearance / bioavailability (CL / F) ratio was lower than the youth group, the index and endogenous creatinine clearance rate There is a positive correlation between. The authors measured the pharmacokinetics and pharmacodynamics of enalapril for 8 days in the elderly (65-78 years old) and youth (22-31 years) healthy people at a daily dose of 10 mg. Results: The maximum reduction of systolic blood pressure in the elderly group and the young group was 58 ± 22 and 25 ± 19 mmHg respectively, with significant differences between the two groups (P <0.02). The CL / F values were 11.3 ± 3.0 and 19.8 ± 5.9 L per hour, respectively, and the baseline values for endogenous creatinine clearance were 64 ± 12 and 124 ± 19 ml / min, respectively