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目的: 观察血必净联合支气管肺泡灌洗辅助治疗重症肺部感染的临床疗效及安全性.方法: 重症肺部感染患者110例按入院单双号分为观察组和对照组各55例.对照组患者在常规治疗基础上给予支气管肺泡灌洗治疗,观察组患者应用血必净联合支气管肺泡灌洗治疗.观察两组疗效和药品不良反应,应用临床肺部感染评分(CPIS) 和急性生理与慢性健康Ⅱ(APACHE-Ⅱ)评分评估患者治疗前后肺部感染程度及预后.记录患者治疗或症状改善时间,检测治疗前后降钙素原(PCT)、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)等血清炎症因子水平.结果: 观察组显效率60.00%,高于对照组的43.64%(P<0.05).治疗后,两组患者CPIS 和APACHE-Ⅱ评分较治疗前明显降低(P<0.05),且观察组明显低于对照组(P<0.05);两组血清PCT、hs-CRP、TNF-α水平均较治疗前显著下降(P<0.05),且观察组均明显低于对照组(P<0.05).观察组机械通气时间、感染控制窗出现时间、呼吸衰竭纠正时间、肺部炎症基本消失时间、应用抗菌药时间均短于对照组(P0.05).结论: 应用血必净联合支气管肺泡灌洗辅助治疗重症肺部感染患者具有较好的临床疗效,预后改善显著,治疗时间缩短,炎症因子水平显著下降,且安全性较好.“,”Objective: To observe the efficacy and safety of Xuebijing combined with bronchoalveolar lavage in the adjunctive therapy of severe pulmonary infection.Methods: Totally 110 patients with severe pulmonary infection were randomly divided into the control group and the observation group according to the admission odd or even number with 55 ones in each.The control group was treated with bronchial lavage on the basis of the conventional therapy.The observation group was treated with Xuebijing combined with bronchoalveolar lavage.The treatment efficacy and adverse reactions were observed, and the degree of lung infection and prognosis were evaluated by the clinical application of pulmonary infection score (CPIS) and acute physiology and chronic health Ⅱ (APACHE-Ⅱ) before and after the treatment.The treatment time or symptom improvement time was recorded, and the serum levels of inflammatory cytokines before and after the treatment were detected.Results: The effective rate of the observation group was 60.00%, which was higher than that of the control group (43.64%, P<0.05).CPIS and APACHE-Ⅱ scores in both groups decreased after the treatment, and those of the observation group were lower than those of the control group (P<0.05).The levels of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) in both groups decreased after the treatment, and those of the observation group were lower than those of the control group (P<0.05).The time of mechanical ventilation, infection control window appearance and respiratory failure correction, pulmonary inflammation disappearance and antibiotics application of the observation group was shorter than that of the control group (P0.05).Conclusion: Xuebijing combined with bronchoalveolar lavage shows better clinical efficacy in the adjunctive therapy of severe pulmonary infection with improved prognosis, shorter treatment time, decreased levels of inflammatory factors and promising security.