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先天性巨结肠是一种常见的小儿先天性肠道发育畸形,发病率约为1/5 000[1]。先天性巨结肠治疗主要以手术为主,术中病理诊断是确定肠管切除范围的金标准。诊断先天性巨结肠强调病变肠段黏膜下神经丛和肌间神经丛神经节细胞完全缺如,同时伴神经纤维增生,两者缺一不可;而先天性巨结肠同源病尽管可出现病变肠段黏膜下神经丛和肌间神经丛神经节细胞减少、甚至缺如,但并不伴有神经纤维增生[2]。这就对组织切面的要求特别高。然而临床送检常为活检标本,组织特别小,所以在制片时相对于其他的组织要
Hirschsprung’s disease is a common congenital intestinal malformations in children, the incidence rate of about 1/5000 [1]. Hirschsprung’s disease is mainly based on surgery, intraoperative pathological diagnosis is the gold standard to determine the scope of resection of the bowel. Diagnosis of Hirschsprung ’s disease emphasizes lesions of intestinal submucosal plexus and myenteric plexus ganglion cells completely absent, accompanied by nerve fiber hyperplasia, both indispensable; and homosexual Hirschsprung disease although there may be lesions Segment submucosal plexus and myenteric plexus ganglion cells decreased, or even absent, but not associated with nerve fiber hyperplasia [2]. This requires a particularly high degree of organizational aspects. However, clinical biopsy specimens often biopsy, tissue is particularly small, so compared to other tissues in the production of