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【作用特点】本品系嘌呤类代谢抑制剂,能以脱氧戊糖核苷形式存在于细胞DNA中,以戊糖核苷形式存在于RNA中。它与6-MP有交叉耐药性,但对阿糖胞苷抗药的肿瘤仍有效。动物实验证明,本品和阿糖胞苷合用,毒性低而疗效佳。对阿糖胞苷耐药的情况下,本品和阿糖胞苷合用也有利,因当阿糖胞苷抑制正常细胞后,在一定时间内,骨髓已无能力渗入6-TG,而耐药性的肿瘤细胞DNA合成速度不降,仍可渗入6-TG,结果正常骨髓不受6-TG影响,而肿瘤细胞大
【Features】 This product purine metabolism inhibitors, can deoxy pentose nucleoside in the form of cell DNA, pentose nucleoside in the form of RNA. It is cross-resistant to 6-MP but remains effective against cytarabine-resistant tumors. Animal experiments show that the goods and cytarabine combination, low toxicity and good effect. In the case of cytarabine resistance, this product and cytarabine combination is also beneficial, because when cytarabine inhibits normal cells, in a certain period of time, the bone marrow has no ability to penetrate 6-TG, and drug resistance DNA synthesis rate of tumor cells did not drop, still can penetrate 6-TG, the results of normal bone marrow from 6-TG, and tumor cells