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目的探讨补阳还五汤加减治疗慢性脑供血不足的临床疗效。方法选取2011年1月—2014年6月寿阳县中医院收治的93例慢性脑供血不足患者,随机分为观察组50例和对照组43例。对照组采用肠溶阿司匹林治疗,观察组采用补阳还五汤加减治疗,疗程为4周。治疗结束后,比较两组患者血流动力学指标改善情况(全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原以及红细胞比容)、临床疗效以及不良反应发生情况。结果治疗后观察组患者全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原以及红细胞比容低于对照组,差异有统计学意义(P<0.05);观察组总有效率(94.0%)高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率(10.0%)低于对照组(44.2%),差异有统计学意义(P<0.05)。结论补阳还五汤加减治疗慢性脑供血不足能够显著改善血流动力学,较快缓解患者病情进展,提高治疗效果。
Objective To investigate the clinical effects of Buyang Huanwu Decoction (MDRH) in treating chronic cerebral insufficiency. Methods From January 2011 to June 2014, 93 patients with chronic cerebral insufficiency admitted to Shouyang Hospital of Traditional Chinese Medicine were randomly divided into observation group (50 cases) and control group (43 cases). The control group was treated with enteric-coated aspirin. The observation group was treated with Buyang Huanwu Decoction. The course of treatment was 4 weeks. After treatment, the improvement of hemodynamics index (whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, fibrinogen and hematocrit) were compared between the two groups. The clinical efficacy and adverse reactions were compared. Results After treatment, the observation group of patients with high blood viscosity, whole blood low shear viscosity, plasma viscosity, fibrinogen and hematocrit were lower than the control group, the difference was statistically significant (P <0.05); total effective rate 94.0%) than the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group (10.0%) was lower than that in the control group (44.2%), the difference was statistically significant (P <0.05). Conclusion Supplementing Buyang Huanwu Decoction in treating chronic cerebral insufficiency can significantly improve hemodynamics, relieve the patient’s condition and improve the therapeutic effect.