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目的：研究功能性消化不良（FD）患者的胃排空和胃电特性以及阿米替林对FD的疗效。方法：用双同位素标记SPECT技术和体表胃电图检测42例FD患者服用小剂量阿米替林前后胃运动功能的变化。结果：FD组和对照组液相排空曲线相似，半排空时间（T50）差异无显著性；FD组因相T50较对照组显著延长，胃电节律紊乱率及餐后振幅降低率较对照组显著增加。阿米替林治疗4周后，FD患者的临床症状显著改善，但胃排空异常率及胃电节律无明显改善。结论：阿米替林可能是通过降低胃肠神经的敏感性，而不是通过改善胃排空率或胃电节律发挥作用。临床使用阿米替林以改善FD症状可取得良好效果。
Objective: To investigate gastric emptying and gastric electrical properties in patients with functional dyspepsia (FD) and the efficacy of amitriptyline on FD. Methods: The changes of gastric motor function in 42 FD patients before and after taking a small dose of amitriptyline were detected by double isotope labeled SPECT and surface electrogastrogram. Results: The liquid phase emptying curves of FD group and control group were similar, and the half-emptying time (T50) had no significant difference. FD group had significantly longer phase T50 than the control group, and the rate of gastric electrical rhythm disturbance and postprandial amplitude decreased Group increased significantly. Four weeks after the amitriptyline treatment, the clinical symptoms of FD patients were significantly improved, but the abnormal rate of gastric emptying and gastric electrical rhythm had no significant improvement. CONCLUSIONS: Amitriptyline may play a role in reducing gastrointestinal nerve sensitivity rather than improving gastric emptying rate or gastric electrical rhythm. Clinical use of amitriptyline to improve FD symptoms can achieve good results.