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目的 研究肿瘤坏死因子－ α（ＴＮＦ－ α） 对慢性阻塞性肺疾病（ＣＯＰＤ） 营养状态的影响。方法 用放免法检测３５ 例不同营养状态的ＣＯＰＤ 患者急性加重期和稳定期血清ＴＮＦ－ α水平。结果 营养正常组（Ａ组） 急性加重期和稳定期ＴＮＦ－ α明显低于中度营养不良组（Ｂ组） 和重度营养不良组（Ｃ 组）（ Ｐ ＜ ０－０５， Ｐ ＜ ０－０１）；Ａ、Ｂ组急性加重期明显高于稳定期（ Ｐ＜０－０５），而Ｃ组无显著性变化（ Ｐ＞０－０５）。结论 ＣＯＰＤ患者的营养状态与血清ＴＮＦ－ α水平有一定关系，ＴＮＦ－α增高可能导致ＣＯＰＤ患者病情加重和营养状态恶化。
Objective To study the effect of tumor necrosis factor-α (TNF-α) on the nutritional status of chronic obstructive pulmonary disease (COPD). Methods The level of serum TNF-α in acute exacerbation and stable stage of 35 COPD patients with different nutritional status was detected by radioimmunoassay. Results The levels of TNF-α in acute exacerbation phase and stable phase in normal nutrition group (A group) were significantly lower than those in moderate malnutrition group (B group) and severe malnutrition group (P <0-05, P <0-01 ). The acute exacerbation period in group A and B was significantly higher than that in stable period (P <0-05), but there was no significant change in group C (P> 0-05). Conclusion The nutritional status of patients with COPD is related to the level of serum TNF-α. Increased TNF-α may lead to worsening of COPD and deterioration of nutritional status.