革兰阴性细菌的脂多糖(LPS)在哺乳动物细胞中可诱导多种生物学效应,这对机体抵御革兰阴性细菌入侵起着重要作用;但是如果这种应答过于强烈,就会使机体形成脓毒血症。其他激活剂如γ-干扰素(IFN-γ)或IL-1将大大增强LPS的致死性作用。作者认为,LPS可诱导NF-κB、IFN-γ可激活酪氨酸激酶(JAK_1、JAK_2),此激酶可诱导细胞内无 Gram-negative bacterial lipopolysaccharide (LPS) can induce a variety of biological effects in mammalian cells, which play an important role in the body against Gram-negative bacterial invasion; however, if this response is too strong, the body can form Sepsis. Other activators such as gamma-interferon (IFN-γ) or IL-1 will greatly enhance the lethal effect of LPS. The authors believe that LPS can induce NF-κB, IFN-γ can activate tyrosine kinase (JAK_1, JAK_2), this kinase can induce intracellular