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目的观察激素替代治疗 (HRT)对绝经后妇女子宫肌瘤的影响。方法阴道超声测量 2 6例服用利维爱 (利维爱组 )和 2 7例服用倍美力加安宫黄体酮 (倍美力组 )共 5 3例合并子宫肌瘤妇女的子宫内膜厚度、子宫体积及子宫肌瘤面积 ,分析 HRT后的变化与血清雌二醇、绝经时间的关系。结果两组 HRT后内膜厚度明显增厚 (P<0 .0 1) ;子宫体积、肌瘤面积有所增大 ,但随着 HRT继续逐渐缩小。倍美力组 HRT后雌二醇明显升高 (P<0 .0 1) ,但子宫体积、肌瘤面积并未随着升高而增大。两组绝经 <10年妇女的内膜厚度、子宫体积、肌瘤面积大于绝经≥ 10年者。结论绝经后患有子宫肌瘤妇女长期应用小剂量 HRT是安全的。
Objective To investigate the effect of hormone replacement therapy (HRT) on uterine fibroids in postmenopausal women. Methods Vaginal ultrasound was used to measure the thickness of endometrium in 26 women with leiomyoide (Levi) and 27 women with uterine myoma , Uterine volume and uterine fibroids area, analysis of changes after HRT and serum estradiol, the relationship between menopause. Results The thickness of intima was significantly thicker in both groups after HRT (P <0.01). The volume of uterus and fibroids increased, but gradually decreased with HRT. Betametridine group after estradiol HRT was significantly higher (P <0.01), but the uterine volume, fibroids area did not increase with increasing. In both groups, menopausal women <10 years intima thickness, uterine volume, fibroids larger than menopausal ≥ 10 years. Conclusion Long-term use of small doses of HRT in women with uterine fibroids after menopause is safe.