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目的观察密盖息联合帕米磷酸二钠治疗骨转移癌引起疼痛的治疗效果。方法对58例确诊为骨转移癌的患者随机分为密盖息联合帕米磷酸二钠组和帕米磷酸二钠组,密盖息联合帕米磷酸二钠组予密盖息100IU肌注,1次/d,连续14d。静滴帕米磷酸二钠90mg,每月1次;帕米磷酸二钠组予静滴帕米磷酸二钠90mg,每月1次。两组均每4周重复,共2次。比较两组患者的止痛效果、生活质量以及血钙和碱性磷酸酶水平。结果密盖息联合帕米磷酸二钠组止痛效果及生活质量均优于帕米磷酸二钠组。两组比较有显著性差异(P<0.01),两组均无严重不良反应。结论密盖息联合帕米磷酸二钠组在骨转移癌止痛、改善生活质量以及生化指标方面明显优于帕米磷酸二钠组,且无严重不良反应。
Objective To observe the effect of treatment of pain caused by bone metastases with polymycin and pamidronate. Methods 58 patients diagnosed with bone metastases were randomly divided into two groups: Mesaliphil combined with pamidronate disodium group and pamidronate disodium group. Methiliplin combined with pamidronate disodium group was intramuscularly infused with 100 IU intramuscularly. 1 time/d for 14 days. Intravenous pamidronate 90 mg once a month; Pamidronate disodium infusion 90 mg pamidronate once a month. Both groups were repeated every 4 weeks for a total of 2 times. The analgesic effect, quality of life, and serum calcium and alkaline phosphatase levels were compared between the two groups. RESULTS: The analgesic effect and quality of life of the melatonin combined with pamidronate disodium group were better than that of the pamidronate disodium group. There was a significant difference between the two groups (P<0.01). No serious adverse reactions were found in both groups. Conclusions Mithali combined with pamidronate disodium group was significantly superior to pamidronate disodium group in the treatment of pain, improvement of quality of life and biochemical indicators of bone metastases, and no serious adverse reactions.