用磷酸羟基哌喹预防性治疗大鼠矽肺,结果表明用药期间(除染尘后7天)支气管肺泡冲洗液(BALF)中总蛋白、总磷脂及磷脂谱低于石英组,停药后二棕榈酰卵磷脂(DPPC)升高,肺泡Ⅱ型细胞增生增殖,说明该药影响肺表面活性物质的代谢。BALF中生化指标的变化遵循一定的规律,把总蛋白、总磷脂,DPPC和脑磷脂(PE)结合起来作为评价药物疗效指标比常用的全肺胶原蛋白和病理学改变出现早。 Propofol hydroxyaproquat prophylaxis treatment of silicosis in rats, the results show that during the medication (except for 7 days after staining) bronchoalveolar lavage fluid (BALF) in total protein, total phospholipids and phospholipid spectrum was lower than the quartz group, after the withdrawal of the two palm Acyl lecithin (DPPC) increased, proliferation and proliferation of alveolar type Ⅱ cells, indicating that the drug affect the metabolism of pulmonary surfactant. The change of biochemical indexes in BALF followed certain rules, and the combination of total protein, total phospholipids, DPPC and cephalosporin (PE) as indicators of drug efficacy appeared earlier than common pulmonary collagen and pathological changes.