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目的:探讨支气管肺泡灌洗液(BALF)及血清中IL6水平与非小细胞肺癌(NSCLC)的关系。方法:应用ELISA检测62例NSCLC患者、36例肺部炎性病患者及正常对照组BALF和血清中IL6的水平。结果:(1)NSCLC患者BALF中IL6的水平显著高于肺部炎性病患者及高于正常对照组(P<0.01)。而NSCLC患者血清中IL6的水平显著高于正常人血清IL6含量水平(P<0.01),略高于肺部炎性病患者,但无统计学意义。(2)NSCLC患者BALF中IL6的水平稍高于血清IL6的水平,但无显著性差异(P>0.05)。(3)Ⅲa、Ⅲb及Ⅳ期NSCLC患者血清IL6的水平显著高于ⅠaⅡb期;而BALF中IL6的水平则无显著增加。(4)NSCLC患者血清IL6的水平与急性炎症反应呈正相关(r=0.74);而BALF中IL6的水平与急性炎症反应无关。结论:BALF中IL6水平的测定可作为NSCLC早期辅助诊断的指标之一;血清IL6的水平可作为判断NSCLC分期的指标。血清IL6水平的增加可反映急性炎症反应的程度。
Objective: To investigate the relationship between bronchoalveolar lavage fluid (BALF) and serum IL6 levels and non-small cell lung cancer (NSCLC). Methods: The levels of IL-6 in BALF and serum of 62 patients with NSCLC, 36 patients with pulmonary inflammatory disease and normal controls were detected by ELISA. Results: (1) The level of IL6 in BALF in patients with NSCLC was significantly higher than that in patients with pulmonary inflammatory disease and higher than that in normal controls (P <0.01). The level of IL6 in serum of NSCLC patients was significantly higher than that of normal people (P <0.01), but slightly higher than that of patients with pulmonary inflammatory disease, but there was no statistical significance. (2) The level of IL6 in BALF of NSCLC patients was slightly higher than that of serum IL6, but there was no significant difference (P> 0.05). (3) The serum levels of IL6 in patients with stage Ⅲa, Ⅲb and Ⅳ NSCLC were significantly higher than those in stage Ⅰa and Ⅱb, while the levels of IL6 in BALF were not significantly increased. (4) There was a positive correlation between serum IL6 level and acute inflammation in patients with NSCLC (r = 0.74). The level of IL6 in BALF was not related to acute inflammation. Conclusion: The determination of IL6 level in BALF can be used as one of the indicators of early diagnosis of NSCLC. The level of serum IL6 can be used as an index to determine the stage of NSCLC. The increase of serum IL6 level can reflect the degree of acute inflammatory reaction.