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B7∶CD28家族成员Programmed death 1(PD-1)在调控T细胞功能中发挥着重要作用,其通过与配体PD-L1、PD-L2结合向T细胞内传递抑制信号,防止T细胞过度活化。近期研究表明,PD-1与肿瘤以及慢性病毒感染进程密切相关,衰竭性CTL细胞(cytotoxic Tlymphocytes)是其研究的热点之一,PD-1的
B7: CD28 family member Programmed death 1 (PD-1) plays an important role in the regulation of T cell function by binding inhibitory signals to T cells via binding to ligands PD-L1 and PD-L2 and preventing T cell over-activation . Recent studies have shown that PD-1 is closely related to the progression of tumor and chronic viral infection, and cytotoxic T lymphocytes are one of its hot topics. PD-1