糖尿病(DM)是一种慢性进行性代谢性疾病,晚期可发生多种急慢性并发症,其对血管的损害是周身多系统损害的病理基础。目前对DM血管损害的研究正在逐步深入。其中,DM血管重构在DM早期血管结构和功能异常及晚期并发症发生中的作用日趋明显。本文就其定义、病理生理、发生机制及防治等方面作一简要综述。 1 DM血管重构的定义及病理生理 血管壁是个能感受、整合急慢性刺激,并能作出反应的器官。它的结构和组成成分并不是一成不变,而是处于持续、复杂的变化之中。患DM时,由于高血糖、胰岛素抵抗、内皮细胞功能紊乱、非酶促糖基化、血液流变学及血流动力 Diabetes mellitus (DM) is a chronic and progressive metabolic disease, which can occur in a variety of acute and chronic complications in the late stage. Its damage to the blood vessels is the pathological basis of multiple systemic injuries in the whole body. The current research on DM vascular damage is gradually in-depth. Among them, the role of DM vascular remodeling in the early vascular structure and function of DM and the occurrence of late complications have become increasingly evident. This article gives a brief overview of its definition, pathophysiology, mechanism of occurrence and prevention and treatment. 1 DM Definition of vascular remodeling and pathophysiology The vascular wall is an organ that can sense and integrate acute and chronic stimuli and respond to it. Its structure and composition are not static, but are in constant, complex changes. When suffering from DM, due to hyperglycemia, insulin resistance, endothelial dysfunction, non-enzymatic glycosylation, hemorheology and hemodynamics