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目的研究HPV-DNA亚型联合液基细胞学检测对宫颈癌筛查的临床意义。方法回顾性分析120例宫颈上皮内瘤变和宫颈癌患者的病历资料,分为接受HPV-DNA亚型检测联合液基细胞学检查的观察组(68例)和仅接受液基细胞学检查的对照组(52例),观察两组患者中筛查阳性情况以及观察组患者中HPV-DNA亚型的阳性例数。结果观察组检出阳性总例数54例,HPV-DNA-16阳性率79.41%、HPV-DNA-18阳性率67.65%,其中CINⅠ级7例、CINⅡ11例,均明显多于对照组;CINⅢ级17例、宫颈浸润癌20例,与对照组无差异。结论 HPV-DNA亚型联合液基细胞学检测对早期发现并诊断宫颈癌有临床意义。
Objective To study the clinical significance of HPV-DNA subtype combined with liquid-based cytology in cervical cancer screening. Methods The clinical data of 120 patients with cervical intraepithelial neoplasia and cervical cancer were retrospectively analyzed. They were divided into observation group (68 cases) receiving HPV-DNA subtype detection combined with liquid-based cytology and those receiving only liquid-based cytology In the control group (52 cases), the positive cases of screening and the positive cases of HPV-DNA subtypes in the observation group were observed. Results In the observation group, 54 cases were positive, the positive rate of HPV-DNA-16 was 79.41%, the positive rate of HPV-DNA-18 was 67.65%, including 7 cases of CINⅠand 11 cases of CINⅡ, 17 cases, 20 cases of invasive cervical cancer, no difference with the control group. Conclusion HPV-DNA subtypes combined with liquid-based cytological detection of early detection and diagnosis of cervical cancer have clinical significance.