吗啡及其同类物用于控制术后疼痛。吗啡口服时的首过效应大,故口服给药时其血浆浓度降低。因而本品常以静脉给药。有关吗啡口腔给药的吸收和效能已在40名男性矫形外科病人中进行研究。吗啡口腔和肌注给药上镇痛效果已作了前瞻性双盲,双空白比较研究。实验设计是每个受试者同时接受吗啡口含片剂和肌肉注射剂,另一组是应用安慰剂和含吗啡的硫酸盐(13.3mg)。20名患者接受每种有效制剂。术后镇痛是以减少疼痛记分和缓解疼痛记分进行评定。采集血样并分析吗啡浓度。结果发现,所提供的两种制剂镇痛程度相同;吗啡的峰血浆浓度口腔给药时较肌注时稍低。然而 Morphine and its like are used to control postoperative pain. First-pass morphine orally when the effect is large, so when oral administration of plasma concentration decreased. This product is often given intravenously. Absorption and efficacy of oral morphine has been studied in 40 male orthopedic patients. Morphine oral administration and intramuscular injection of analgesic effect has been made prospective double-blind, double blank comparative study. The experimental design was that each subject received both morphine buccal and intramuscular injections and the other placebo and morphine-containing sulphate (13.3 mg). Twenty patients received each active formulation. Postoperative analgesia is based on the reduction of pain scores and pain relief scores. Blood samples were taken and analyzed for morphine concentration. The results showed that the two formulations provided had the same degree of analgesia; the peak plasma concentration of morphine was slightly lower when administered orally than during intramuscular administration. however