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目的:观察地诺前列酮栓用于羊水偏少妊娠引产的临床效果及安全性。方法:选择孕周>36周、两次B超提示羊水指数≤8cm的无阴道分娩禁忌孕妇80例,随机分为观察组与对照组各40例;观察组以阴道放置地诺前列酮栓引产,对照组采用传统催产素引产,比较两组用药后6h、12h宫颈Bishop评分、分娩发生时间、剖宫产率和对胎儿及新生儿的影响。结果:(1)观察组孕妇给药6h后Bishop评分提高(2.32±1.16)分,对照组提高(0.74±0.24)分,给药12h后观察组提高(3.92±1.14)分,对照组提高(1.24±0.18)分,两组比较,差异均非常显著(P<0.01)。(2)观察组从给药到临产时间为(17.4±10.2)h,对照组为(54.2±36.4)h,两组比较,差异非常显著(P<0.01)。(3)观察组剖宫产16例(40.0%),对照组25例(62.5%),两组比较,差异非常显著(P<0.01)。(4)两组孕妇产程中胎心变化、羊水异常发生率,以及新生儿出生时状况无显著差异。结论:地诺前列酮用于羊水偏少妊娠引产临床效果较好。
Objective: To observe the clinical effect and safety of dinoprostone suppository in induction of labor with partial pregnancy of amniotic fluid. Methods: Eighty pregnant women with taboo gestational age> 36 weeks who had B-ultrasound to show amniotic fluid index <8cm were randomly divided into observation group and control group with 40 cases each. The observation group received dianostone suppository . The control group received conventional oxytocin induction. The Bishop cervical score, delivery time, cesarean section rate, and fetal and neonatal effects at 6h and 12h after treatment were compared between the two groups. Results: (1) The Bishop score (2.32 ± 1.16) and the control group increased (0.74 ± 0.24) after 6h administration in the observation group, the observation group increased (3.92 ± 1.14) and the control group increased after 12h 1.24 ± 0.18) points, the differences between the two groups were significant (P <0.01). (2) The time from administration to labor was (17.4 ± 10.2) h in the observation group and (54.2 ± 36.4) h in the control group. The difference between the two groups was significant (P <0.01). (3) There were 16 cases (40.0%) in the observation group and 25 cases (62.5%) in the control group. The differences between the two groups were significant (P <0.01). (4) There was no significant difference in fetal heart rate, the incidence of amniotic fluid abnormality and the birth of newborns between the two groups during labor. Conclusion: The use of dinoprostone for induction of labor with amniotic fluid partial pregnancy is better.