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为探讨并控制肾病综合征皮质激素中长程疗法对青春前期身高发育的影响，应用放射免疫法（RIA）测定40例青春前期肾病综合征患儿血清生长激素（GH）水平。结果肾病综合征血清GH显著低于正常对照组（P＜0．01），GH与能表明肾功能状态的SCr、BUN、Sβ2-MG、Uβ2-MG是显著负相关，与皮质激素的总剂量、总疗程呈显著负相关（P均＜0．01）。提示皮质激素中、长程疗法及肾脏病本身均可明显影响青春前期肾病综合征患儿的身高发育。
In order to explore and control the effect of mid-long term therapy of nephrotic syndrome (corticosteroid) on height development of adolescence, the level of serum growth hormone (GH) in 40 cases of pre-adolescent nephrotic syndrome was determined by radioimmunoassay (RIA). Results Serum GH of nephrotic syndrome was significantly lower than that of the normal control group (P <0.01). GH was negatively correlated with SCr, BUN, Sβ2-MG and Uβ2-MG, which could indicate the renal functional status. , The total course of treatment was significantly negatively correlated (P <0.01). Tip corticosteroids, long-term therapy and kidney disease itself can significantly affect the height of children with pre-nephrotic syndrome.