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目的了解女性卵泡刺激素(FSH)和黄体生成素(LH)水平的变化与各种骨转换生化指标之间的关系。方法健康女性694例,年龄20～82岁。放射免疫法测定血清FSH和LH,ELISA测定血清骨特异性碱性磷酸酶(BAP)、骨钙素(OC)、骨Ⅰ型胶原N末端肽(sNTX)和C末端肽(sCTX)、尿骨Ⅰ型胶原N末端肽(uNTX)和C末端肽(uCTX)、尿骨Ⅰ型胶原交联脱氧吡啶酚(uDPD)。结果血清FSH和LH与BAP、OC、sCTX、uNTX和uDPD之间的关系,采用复合曲线模型拟合优度最佳,与sNTX和uCTX之间的关系采用线性模型拟合优度最佳,FSH和LH与BAP(R2=0.392和0.382,P=0.000)之间的决定系数最大,与uDPD(R2=0.027和0.017,P=0.002)之间的决定系数最小。多元线性回归分析显示,BAP43.0%、OC22.1%、uCTX11.8%、sNTX8.2%、uNTX8.2%、sCTX6.6%和uDPD1.9%的变化是由FSH决定的,LH只能解释0.7%～2.1%的变化,FSH对各种骨转换指标的决定性作用大约是LH的7～20倍。结论女性FSH和LH水平与骨转换速率有关,血清FSH和LH水平增加者骨转换增加,FSH对骨转换的作用远大于LH,对骨形成指标的作用远大于骨吸收指标。
Objective To investigate the relationship between the changes of female follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels and the biochemical markers of bone turnover. Methods 694 healthy women, aged 20 to 82 years old. Serum FSH and LH were measured by radioimmunoassay. Serum bone-specific alkaline phosphatase (BAP), osteocalcin (OC), bone mineral collagen type Ⅰ collagen (sNTX) and C-terminal peptide Type I collagen N-terminal peptide (uNTX) and C-terminal peptide (uCTX), urinary collagen type I collagen crosslinked deoxypyridinol (uDPD). Results The relationship between serum FSH and LH and BAP, OC, sCTX, uNTX and uDPD was best fitted by composite curve model, and the relationship between sNTX and uCTX was best by linear model. FSH And the determination coefficient between LH and BAP (R2 = 0.392 and 0.382, P = 0.000) was the largest, and the determination coefficient between uDPD (R2 = 0.027 and 0.017, P = 0.002) was the smallest. Multivariate linear regression analysis showed that the changes of BAP43.0%, OC22.1%, uCTX11.8%, sNTX8.2%, uNTX8.2%, sCTX6.6% and uDPD1.9% were determined by FSH and LH Can explain the changes of 0.7% to 2.1%, FSH on the various bone turnover indicators of the decisive role is about 7 to 20 times the LH. Conclusions Female FSH and LH levels are related to bone turnover rate. Increased serum FSH and LH levels increase bone turnover. The effect of FSH on bone turnover is much greater than that of LH. The effect on bone formation is much greater than that of bone resorption.