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目的:探讨颈动脉内膜中层厚度(IMT)与血清学相关指标水平变化对糖耐量异常人群病情和预后的影响。方法:行葡萄糖耐量试验(OGTT),将112例糖耐量减低(IGT)患者作为IGT组,126例糖耐量正常(NGT)体检者作为NGT组,98例新发2型糖尿病(DM)患者作为DM组,采用彩色多普勒超声检查仪行颈动脉彩超检查,检测各组IMT水平;采用全自动生化分析仪测定血清学指标浓度。并进行统计学分析。结果:IGT组、DM组FBG、2hPG、FINS、HbA1c、TC、LDL-C、HOMA-IR、OGTT、IMT厚度均高于NGT组;DM组FBG、2hPG、FINS、HOMA-IR、OGTT、IMT厚度较IGT组显著升高,差别均有统计学意义(P<0.05或P<0.01)。结论:平均年龄、BMI、2hPG、FINS、HbA1c、LDL-C、HOMA-IR、OGTT均是IGT、DM(糖耐量异常)人群IMT增厚的密切相关因素;对临床IGT患者进行护理干预与宣教,进一步提高治疗效果,改善预后,有助于延缓DM和心脑血管病发生、发展。
Objective: To investigate the influence of carotid artery intima-media thickness (IMT) and serological markers on the condition and prognosis of patients with impaired glucose tolerance. Methods: One hundred and twelve patients with IGT were enrolled as IGT group and 126 with normal glucose tolerance (NGT) as NGT group. 98 patients with newly diagnosed type 2 diabetes mellitus (DM) DM group, using color Doppler ultrasound examination of carotid color Doppler ultrasound examination to detect the level of IMT; using automatic biochemical analyzer serological indicators concentration. And statistical analysis. Results: The thickness of FBG, 2hPG, FINS, HbA1c, TC, LDL-C, HOMA-IR, OGTT and IMT in IGT group and DM group were higher than that in NGT group. FBG, 2hPG, FINS, The thickness was significantly higher than IGT group, the difference was statistically significant (P <0.05 or P <0.01). Conclusions: The average age, BMI, 2hPG, FINS, HbA1c, LDL-C, HOMA-IR and OGTT are closely related factors of IMT thickened in IGT and DM patients. Nursing intervention and mission , To further improve the treatment effect and improve the prognosis, help to delay the occurrence and development of DM and cardiovascular and cerebrovascular diseases.