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目的探讨慢性阻塞性肺疾病患者血清肺表面活性蛋白D水平变化及其临床意义。方法选取COPD急性加重期患者30例、COPD稳定期患者30例及对照者30例,分别测定其血清SP-D水平,并与COPD患者严重程度进行相关分析。结果 COPD急性加重、稳定期患者血清SP-D水平均高于对照组(P<0.05);COPD急性加重组患者血清SP-D水平明显高于稳定期组(P<0.05)。相关性分析结果显示:COPD急性加重、稳定期患者血清SP-D水平与一秒钟用力呼气容积占预计值百分比(FEVl%pred)均呈负相关(P<0.05)。结论 COPD急性加重、稳定期患者血清SP-D水平均高于对照组,血清SP-D水平变化可作为判定COPD病情严重程度的指标之一。
Objective To investigate the changes of serum pulmonary surfactant protein D levels in patients with chronic obstructive pulmonary disease and its clinical significance. Methods Thirty patients with acute exacerbation of COPD, 30 patients with stable COPD and 30 controls were enrolled in this study. Serum SP-D levels were measured and correlated with the severity of COPD. Results Serum SP-D levels in patients with acute exacerbation of COPD were significantly higher than those in stable patients (P <0.05). Correlation analysis showed that the level of SP-D in acute exacerbation of COPD patients was negatively correlated with FEVl% pred of forced expiratory volume in one second (P <0.05). Conclusion The serum levels of SP-D in patients with acute exacerbation of COPD and those in stable patients are higher than those in the control group. The change of serum SP-D levels may be used as one of the indicators to determine the severity of COPD.