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目的观察马来酸桂哌齐特治疗老年高血压并突发性耳聋的疗效及对血清超氧化物歧化酶(SOD)和脂质过氧化反应产物丙二醛(MDA)的影响。方法63例老年高血压并突聋患者随机分为2组,常规治疗组32例,常规治疗加马来酸桂哌齐特组31例,分别与治疗前后检查患者听功能及测定血清SOD和MDA,并与30例健康人做对照。结果常规治疗加马来酸桂哌齐特组与常规治疗组比较总有效率明显升高(P<0.05);SOD明显升高(P<0.05),MDA明显降低(P<0.05)。结论在常规治疗的基础上加用马来酸桂哌齐特治疗,疗效优于常规疗法,且安全,无明显不良反应。
Objective To observe the effect of cinepazide maleate on senile hypertension and sudden deafness and its effect on serum superoxide dismutase (SOD) and lipid peroxidation product malondialdehyde (MDA). Methods Sixty-three elderly hypertensive patients with sudden deafness were randomly divided into two groups: conventional treatment group (n = 32), conventional treatment plus cinepazide maleate (n = 31), and the patients’ hearing function and serum SOD and MDA , And compared with 30 healthy people. Results The results showed that the total effective rate was significantly higher in conventional treatment plus cinepazide maleate group than that in the conventional treatment group (P <0.05); the SOD level increased significantly (P <0.05); MDA decreased significantly (P <0.05). Conclusion The addition of cinepazide maleate on the basis of conventional treatment has better curative effect than conventional therapy and is safe and has no obvious adverse reactions.