论文部分内容阅读
目的探讨212例下呼吸道鲍曼不动杆菌感染分布表现、耐药性特点及多重耐药菌的易感因素。方法 2010年4月至2012年4月我院收治212例下呼吸道感染患者,对其分离出的212株鲍曼不动杆菌进行调查,分析其分布、耐药性及多重耐药性患者和非多重耐药性患者两者间的易感因素。结果 212例下呼吸道感染患者分离出鲍曼不动杆菌212株,其中多重耐药80株,主要分布在重症监护病房(ICU),其次为呼吸内科、神经内科等。2010-2012年多重耐药的鲍曼不动杆菌构成比例分别36.2%、36.7%、39.2%;其特点是对多粘菌素B最为敏感,其次是替加环素;对含有β-内酰胺酶抑制剂复方制剂抗菌类药物均表现为明显的耐药性。结论鲍曼不动杆菌对多粘菌素B最为敏感,其次是替加环素,对碳青霉素烯类抗菌药物其耐药性呈现逐步上升的趋势;使用不同抗菌药物、并发心脑血管疾病以及病情变化成为多重耐药菌感染的主要易感因素。
Objective To investigate 212 cases of lower respiratory tract infection Acinetobacter baumannii distribution, resistance characteristics and multi-resistant bacteria susceptibility factors. Methods From April 2010 to April 2012, 212 patients with lower respiratory tract infection were treated in our hospital. 212 strains of Acinetobacter baumannii isolated from our hospital were investigated. The distribution, drug resistance and multidrug resistance were analyzed Multidrug resistance in patients with susceptibility factors. Results A total of 212 strains of Acinetobacter baumannii were isolated from 212 patients with lower respiratory tract infection, of which 80 were multidrug-resistant. They were mainly distributed in intensive care unit (ICU), followed by respiratory medicine and neurology. The percentage of multi-drug resistant Acinetobacter baumannii from 2010 to 2012 was 36.2%, 36.7% and 39.2%, respectively. It was the most sensitive to polymyxin B, followed by tigecycline, Enzyme Inhibitors Compound preparations antibacterial drugs showed obvious resistance. Conclusion Acinetobacter baumannii is the most sensitive to polymyxin B, followed by tigecycline, its resistance to carbapenem-based antimicrobial agents shows a gradual upward trend; using different antibiotics, cardiovascular and cerebrovascular diseases and Disease changes become the main susceptibility factor for multi-drug resistant bacteria infection.