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FHIT基因是在1996年被Ohta从人染色体3p14.2分离出来的一个新的侯选抑癌基因,该基因在多种肿瘤中都有异常改变。据国外文献报道在头颈部肿瘤中也存在FHIT基因的异常转录本,目前国内外尚未见有关的研究报道。我们将人正常FHIT基因全长cDNA克隆入真核表达载体pcDNA3.1,为进一步探讨FHIT基因在头颈部肿瘤中的作用做准备。
The FHIT gene was a novel candidate tumor suppressor gene that was isolated from human chromosome 3p14.2 by Ohta in 1996 and has abnormal changes in many tumors. According to foreign literature, there are also abnormal transcripts of FHIT gene in head and neck cancer. At present, no relevant research reports have been reported at home and abroad. We cloned human full-length cDNA of FHIT gene into the eukaryotic expression vector pcDNA3.1, in order to further investigate the role of FHIT gene in head and neck cancer.