目的:制备以果胶钙为载体材料,芦丁为模型药物的骨架型结肠定位小丸,并考察其体外释放特征。方法:采用液中固化法制备果胶钙骨架型小丸并优化其工艺参数,以紫外分光光度法测定其体外释放度。结果:制备芦丁果胶钙小丸的最佳工艺参数:氯化钙质量分数为10%,钙化时间为2h,低甲氧基果胶质量分数为5%。所得小丸初步具备结肠定位释药系统的特征。结论:以果胶钙为载体材料采用液中固化法制备结肠定位小丸工艺可行。 OBJECTIVE: To prepare skeletal colon-positioned pellets with pectin as carrier and rutin as model drug, and investigate its in vitro release characteristics. Methods: Pectin-calcium matrix pellets were prepared by liquid-solid method and its processing parameters were optimized. The in vitro release was determined by UV spectrophotometry. Results: The optimal parameters of preparation of rutin pectin calcium pellets were as follows: calcium chloride 10%, calcification time 2 h and low methoxyl pectin 5%. The resulting pellets initially possess the characteristics of a colon-targeted drug delivery system. Conclusion: It is feasible to prepare colonic pellets by solidification method using calcium pectinate as carrier material.