Interactions of ciprofloxacin hydrochloride(CPFH)with sodium dodecyl sulfate(SDS)were investigated by conductivity measurement in H2O/electrolyte solutions(NaCl,Na2SO4&Na3PO4)over 298.15-318.15 K temperature range(with 5 K interval)considering the human body temperature.In all cases,two critical micelle concentrations(c*)were observed which are increased in the presence of drug and decreased in the presence of salts enunciating the presence of interaction amongst the studied components.For(CPFH+SDS)system in the presence of salt,the c*values at 303.15 K and I=0.50 mmol·kg-1 followed the order: CNaCl＞CNa2SO4＞CNa3PO4.The ΔG0 1,m and ΔG02,m values are found to be negative for all systems that show that the micellization process is thermodynamically spontaneous.For(CPFH+SDS)system in water,the ΔH0m&ΔS0mvalues reveal that the micellization processes is both entropy dominated in almost all cases.In the occurrence of electrolytes,ΔH0m and ΔS0m values indicate that micellization processes are both entropy&enthalpy restricted at upper temperature but it becomes totally entropy dependent at higher temperature.The higher positive ΔS0m values indicate the enhanced hydrophobic interaction in pres-ence of salts.The enthalpy-entropy compensation was determined from the linear relationship between ΔH0m and ΔS0m values in every state.Different transfer energies as well as compensation temperature and intrinsic enthalpy were also evaluated and the behaviors were comparable to other biological system.