近年来,使用抗肿瘤药物产生的血管毒性作用日趋增多。作者复习了与细胞毒化疗相关的血管并发症。肺静脉阻塞性疾病(PVOD) PVOD 是肺原性高血压的罕见病因之一。其特征性的组织学所见为肺静脉和小静脉因疏松结缔组织、含有少量细胞成份的结缔组织、或偶因富含胶原的结缔组织充填而阻塞或狭窄。发病机制可能涉及到呼吸道感染和免疫性失调以及毒素的 In recent years, the use of anti-tumor drugs to produce increased role of vascular toxicity. The authors reviewed the vascular complications associated with cytotoxic chemotherapy. Pulmonary Vein Obstructive Disease (PVOD) PVOD is one of the rare causes of pulmonary hypertension. Its characteristic histology shows that pulmonary veins and venules are obstructed or stenosed by loose connective tissue, connective tissue containing a small amount of cellular components, or even by collagen-rich connective tissue. The pathogenesis may involve respiratory infections and immune disorders as well as toxins