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由6氨基青霉烷酸(6APA)经桑德迈尔反应、氧化、酯化、开环、氯化环合五步反应合成泰唑巴坦中间体———2β氯甲基2α甲基6α溴青霉烷酸对硝基苄酯.
Synthesis of tazobactam intermediates from 2 aminopenicillanic acid (6APA) by Sander-Meyer reaction, oxidation, esterification, ring-opening and chlorination cyclization --- 2βchloromethyl 2α methyl 6α Bromopenicillanic acid p-nitrobenzyl ester.