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以甲氨喋呤为主的早期化疗方案(Ⅰ组)和金字塔方案(Ⅱ组),分别治疗幼年类风湿性关节炎各25例。Ⅰ、Ⅱ组总有效率分别为88%和64%,副反应发生率为12%和48%(x~2=3.94,7.71,P均<0.05)。对31/50例进行了11~120个月的随访,Ⅰ组(14例)和Ⅱ组(17例)的远期缓解率为92.86%和41.18%(x~2=8.96,P<0.005)。Ⅱ组3例死亡,6例残疾,Ⅰ组尚未发现此类结果。上述结果表明,以甲氨喋呤为主的早期化疗方案,对本病的治疗是安全有效的。
Methotrexate-based early chemotherapy (Ⅰ group) and pyramid program (Ⅱ group) were treated in juvenile rheumatoid arthritis in 25 cases. The total effective rates of group Ⅰ and group Ⅱ were 88% and 64% respectively. The incidences of side effects were 12% and 48% (x ~ 2 = 3.94 and 7.71, P <0.05 respectively). The long-term remission rates of group Ⅰ (14 cases) and group Ⅱ (17 cases) were 92.86% and 41.18% (x ~ 2 = 8.96, P <0.005) after 31 to 50 months of follow- . Three patients died in group Ⅱ and six were disabled. No such result was found in group Ⅰ. The above results show that methotrexate-based early chemotherapy, the treatment of this disease is safe and effective.