论文部分内容阅读
目的 :观察诺和龙降低 2型糖尿病患者餐后血糖的效果及对糖化血红蛋白和C肽的影响 ,并与优降糖进行对比研究。方法 :诺和龙组 45例 ,男 2 6例 ,女 19例 ,平均年龄 48 2 2± 6 19岁 (32～ 78岁 ) ,优降糖组 45例 ,男 2 4例 ,女 2 1例 ,平均年龄 46 71± 7 6 8岁 (35～ 71岁 ) ,观察指标为血糖、糖化血红蛋白、胰岛素。第一天停用口服降糖药 ,检测糖化血红蛋白 ,胰岛素和 10 0克馒头餐后 1小时、 2小时血糖 ;第二天以后每日早晨空腹测血糖 ,分别服诺和龙 1mg、优降糖5mg ,并且检测 10 0克馒头餐后 1小时和 2小时血糖 ,连续半月 ,第 15天再次检测糖化血红蛋白和胰岛素。结果 :诺和龙组餐后 1小时血糖下降 36 74% ,餐后 2小时血糖下降 2 8 5 1% ;而优降糖组分别下降 2 4 0 8%、 30 17% (P <0 0 1,P >0 0 5 ) ;半月后糖化血红蛋白分别下降 33 42 %、 19 91% (P <0 0 5 ) ;餐后 1小时胰岛素分别上升 42 2 2 %、 11 2 4% (P <0 0 1) ;餐后 2小时胰岛素分别上升 31 2 9%、 32 94% (P >0 0 5 )。结论 :诺和龙降低餐后血糖 (特别是餐后 1小时血糖 )和升高餐后 1小时胰岛素水平的效果明显好于优降糖 ,连续用药后降低糖化血红蛋白的效果也比优降糖更好
OBJECTIVE: To observe the effect of Novolin on reducing postprandial blood glucose in patients with type 2 diabetes mellitus and its effect on glycosylated hemoglobin and C-peptide, and to compare with glyburide. Methods: Nuo-long group of 45 cases, 26 males and 19 females, the average age of 482 2 ± 6 19 years (32 to 78 years), gose group 45 cases, 24 males and 21 females , With an average age of 46 71 ± 7 6 years (35-71 years). The observed indexes were blood glucose, glycosylated hemoglobin and insulin. Oral hypoglycemic agents were discontinued on the first day, glycosylated hemoglobin, insulin, and 1 hour and 2 hours of postprandial glycemia were measured on the 100 grams of steamed bread. The fasting blood glucose was measured daily on the morning after the second day, 5mg, and detected 100 g steamed bread 1 hour and 2 hours postprandial blood glucose, hemoglobin and insulin again for half a month, 15 days. Results: Novo Glucose decreased blood glucose by 36 74% at 1 hour postprandial and blood glucose decreased by 2 851% at 2 hours postprandial, while decreased by 240% and 30 17% respectively (P <0.01) , P> 0.05). Half a month later, the levels of HbA1c decreased by 33 42% and 19 91%, respectively (P 0 05), and increased by 42 2 2% and 112 4% 1). After 2 hours, insulin increased by 31.29% and 32 94% respectively (P> 0.05). CONCLUSION: Novolin can significantly reduce the postprandial blood glucose (especially 1 hour postprandial blood glucose) and increase the 1 hour postprandial insulin level, which is significantly better than that of etoposide. After continuous administration, the effect of lowering HbA1c it is good