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目的:探讨血清降钙素原(PCT)在诊断新生儿感染性疾病的应用价值。方法:选择在我院住院治疗的疑似感染的新生儿65例,根据感染部位及范围分为全身感染组、局部感染组和非感染组,对比观察3组患儿血液PCT、C反应蛋白(CRP)及白细胞(WBC)计数以及PCT与CRP的敏感性。结果:(1)全身感染组PCT、CRP及WBC明显高于局部感染组及对照组(P<0.05),局部感染组PCT明显高于非感染组,CRP及WBC与非感染组差异无统计学意义(P>0.05);(2)全身感染组PCT敏感性为85.2%,CRP为62.7%;局部感染组PCT敏感性为69.5%,CRP为42.7%,;非感染组PCT敏感性12.7%,CRP为38.2%,3组间PCT与CRP敏感性差异有统计学意义(P<0.05)。结论:PCT诊断敏感性高,作为检测指标优于CRP,临床上可以通过对PCT的动态监测对患儿感染程度做出准确判断。
Objective: To investigate the value of serum procalcitonin (PCT) in the diagnosis of neonatal infectious diseases. Methods: Sixty-five neonates suspected to be hospitalized in our hospital were selected and divided into systemic infection group, local infection group and non-infected group according to the site and extent of infection. The levels of PCT, C-reactive protein (CRP) ) And white blood cell (WBC) counts and PCT and CRP sensitivity. Results: (1) The PCT, CRP and WBC in the systemic infection group were significantly higher than those in the local infection group and the control group (P <0.05). The PCT in the local infection group was significantly higher than that in the non-infected group. There was no significant difference between the CRP and WBC groups (P> 0.05). (2) The sensitivity of PCT was 85.2% in systemic infection group and 62.7% in CRP. The PCT sensitivity was 69.5% in local infection group and 42.7% in CRP group. The PCT sensitivity in non-infected group was 12.7% The CRP was 38.2%. The sensitivity of PCT and CRP between the three groups was statistically significant (P <0.05). Conclusion: PCT diagnosis is highly sensitive, as a detection index superior to CRP, clinically through the PCT dynamic monitoring of the extent of infection in children to make accurate judgments.