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目的:探讨新生儿脐血免疫血清学检测在新生儿溶血病中的应用价值。方法:对864例O型血母亲分娩的新生儿进行脐血免疫血清学检验,①ABO血型不合的466例为实验组,母婴O-O血型相合的398例为对照组,研究血清学检测结果对发生新生儿溶血病及高胆红素血症的关系。结果:①ABO血型不合组发生新生儿溶血病率及高胆红素血症显著高于对照组;②母/子血型为O/A组与O/B组抗体释放试验阳性率均有显著差异,而O/A组与O/B组在游离抗体试验及抗人球蛋白试验阳性率均差异无统计学意义;③脐血总胆红素越高发生新生儿高胆红素血症的时间越早;游离抗体试验阳性率、抗体释放试验阳性率、母婴血型O-B型与新生儿黄疸出现的时间(日龄≤3天和日龄>3天)差异有统计学意义。结论:通过对脐血进行血型血清学检验,是早期诊断新生儿溶血病的准确方法,有助于早期诊断新生儿高胆红素血症。
Objective: To investigate the value of neonatal cord blood serology in neonatal hemolytic disease. Methods: 864 neonates with O-type blood mothers were immunized with cord blood for serological tests. ① The 466 cases with incompatible abnomal blood group were selected as the experimental group, and 398 matched maternal and child OO blood group as the control group. Neonatal hemolytic disease and hyperbilirubinemia. Results: ①The hemolytic disease rate and hyperbilirubinemia in the abnomal blood group were significantly higher than those in the control group. (2) There was significant difference in the antibody positive rate between the O / A group and the O / B group in the mother / The O / A group and O / B group in the free antibody test and the anti-human globulin test positive rate was no significant difference; ③ umbilical cord serum total bilirubin newborns with hyperbilirubinemia more time Early; the positive rate of free antibody test, the positive rate of antibody release test, maternal and neonatal OB type and neonatal jaundice appear time (day ≤ 3 days and day of age> 3 days) difference was statistically significant. Conclusion: It is an accurate method to diagnose neonatal hemolytic disease by blood group serological test on cord blood in the early diagnosis of neonatal hyperbilirubinemia.