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1例65岁男性肺癌患者,因不能耐受多种化疗药物遂给予吉非替尼250 mg,1次/d。2 d后患者出现胸闷、气促,双肺可闻及哮鸣音。实验室检查:血SpO20.60,PO263 mm Hg,PCO245 mm Hg,ALT 445U/L,AST 383U/L,LDH 2 277U/L,HBDH968U/L。肺CT示双肺间质纤维化伴感染。停用吉非替尼,同时静脉推注甲泼尼龙、盐酸氨溴索及奥美拉唑,病情无改善,因多器官功能衰竭抢救无效死亡。
One 65-year-old man with lung cancer who received gefitinib 250 mg once daily because of inability to tolerate multiple chemotherapeutic drugs. 2 d after the patient chest tightness, shortness of breath, lungs can be heard and wheeze. Laboratory tests: blood SpO20.60, PO263 mm Hg, PCO245 mm Hg, ALT 445U / L, AST383U / L, LDH2727U / L, HBDH968U / L. Pulmonary CT showed interstitial fibrosis with infection. Gefitinib was discontinued and methylprednisolone, ambroxol hydrochloride and omeprazole were administered intravenously without any improvement in the condition, resulting in multiple deaths due to multiple organ failure.