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目的 :优化淫羊藿黄芪口服液的制备工艺。方法 :以均匀设计法设计提取工艺 ,以黄酮、多糖及淫羊藿苷的含量为指标进行筛选 ;并以此作指标 ,对冷沉法、醇沉法、ZTC1+1Ⅲ型澄清剂法、壳聚糖法的澄清效果进行比较。结果 :提取的优化条件为 :50 %乙醇溶液、9倍于药材的溶剂量、提取二次 (4h、2h) ;两种澄清剂及冷沉法对多糖、黄酮及淫羊藿苷无明显影响 ,效果优于醇沉法。结论 :均匀设计的结果与实际效果相吻合 ,为一可行性的研究方法 ;澄清法优于其他方法 ,为澄清技术改革提供依据。
Objective: To optimize the preparation process of Epimedium astragalus membranaceus oral liquid. Methods: The extraction process was designed with a uniform design method. The content of flavonoids, polysaccharides, and icariin was used as an indicator; this was used as an index for the cold sinking, alcohol precipitation, ZTC1+1 type III clarifier, shell The clarification effect of the glycan method was compared. Results: The optimized conditions for extraction were: 50% ethanol solution, 9 times the amount of solvent used in medicinal materials, extraction twice (4 h, 2 h); two clarifiers and cold precipitation methods had no significant effect on polysaccharides, flavonoids and icariin The effect is better than the alcohol precipitation method. Conclusion: The results of uniform design are consistent with the actual results and are a feasible research method. The clarification method is superior to other methods and provides a basis for clarification of technological reforms.