自身免疫性疾病是机体对自身成分发生免疫应答而导致的疾病状态,其基本特征是自身应答性T淋巴细胞或自身抗体造成相应的组织细胞损伤或功能障碍,血液中可检测到高效价的自身应答性T淋巴细胞和/或自身抗体,且病情的转归与自身免疫应答的强度密切相关。T辅助细胞1型(T-helper cell type 1,Th1)、Th17细胞功能失调可诱导多种自身免疫性疾病的发生[1]。信号转导和转录激活子4(Signal transducer and Autoimmune diseases are the disease states caused by the body’s immune response to its own components. The basic characteristics of autoimmune diseases are the self-reactive T lymphocytes or autoantibodies that cause the corresponding damage or dysfunction of the tissue cells, the self-detectable high titers in the blood Responsive T lymphocytes and / or autoantibodies, and the prognosis of the disease is closely related to the intensity of the autoimmune response. T helper cell type 1 (Th1), Th17 cell dysfunction can induce a variety of autoimmune diseases [1]. Signal transducer and