目的探讨一氧化氮(NO)、内皮素(ET)、6酮前列腺素(6KPGF1α)在脑梗死发病过程中的意义以及与病情、伴发症之间的关系。方法采用比色法及放射免疫分析法测定60例急性脑梗死患者发病后1周内、2、4周时的血清NO浓度,血浆ET及6KPGF1α浓度,并与对照组比较。结果急性脑梗死组血清NO、血浆ET、6KPGF1α浓度均明显升高(P<0.02～0.001);高血脂组NO浓度高于非高血脂组(P<0.05);病情重、中型ET浓度高于轻型(P<0.05),高血压病组高于非高血压病组(P<0.001),冠心病组ET浓度高于非冠心病组(P<0.001);糖尿病组6KPGF1α浓度高于非糖尿病组(P<0.05)。结论NO、ET、6KPGF1α在脑梗死的发生、发展中具有一定作用,并与高血脂、高血压病、冠心病、糖尿病存在一定关系,ET含量变化与病情有关。 Objective To investigate the significance of nitric oxide (NO), endothelin (ET) and 6-ketoprostaglandin (6KPGF1α) in the pathogenesis of cerebral infarction and its relationship with the disease and complication. Methods Serum NO concentration, plasma ET and 6KPGF1α concentrations in 60 patients with acute cerebral infarction within 1 week, 2 and 4 weeks after onset were measured by colorimetry and radioimmunoassay, and compared with the control group. Results Serum levels of NO, plasma ET and 6KPGF1α in acute cerebral infarction group were significantly higher than those in non-hyperlipidemic group (P <0.02 ~ 0.001) (P <0.05), hypertension group was higher than non-hypertension group (P <0.001), coronary heart disease group ET concentration was higher than non-coronary heart disease group (P <0.001), diabetes group 6KPGF1αconcentration was higher than non-diabetic group (P <0.05). Conclusion NO, ET and 6KPGF1α play a role in the occurrence and development of cerebral infarction. They are related to hyperlipidemia, hypertension, coronary heart disease and diabetes. The content of ET is related to the disease.