目的:总结普卡比利的药理和临床疗效,以期为临床合理使用本品提供参考。方法:查阅近期国内外相关文献,对普卡比利的重要药理作用、疗效及不良反应进行归纳、总结。结果:普卡比利为一高度选择性五羟色胺4受体激动剂,能够改善患者的肠功能状况(如增加排便次数、提高患者的生活质量及满意程度等),该药最常见的不良反应为头痛、腹泻、恶心及腹痛等。结论:普卡比利对慢性便秘具有较好的治疗作用,患者容易耐受,不良反应轻微。 OBJECTIVE: To summarize the pharmacological and clinical efficacy of plecbibril in order to provide a reference for the clinical rational use of this product. Methods: To review the recent literature at home and abroad, summarize and summarize the important pharmacological effects, curative effects and adverse reactions of Pucarbili. RESULTS: Pukapride, a highly selective serotonin 4 receptor agonist, improved the patients’ bowel function (such as increasing the frequency of defecation, improving the quality of life and satisfaction of patients, etc.). The most common adverse drug reaction was Headache, diarrhea, nausea and abdominal pain. CONCLUSION: Pukapipil has a good therapeutic effect on chronic constipation. Patients are easy to tolerate with mild adverse reactions.